Recent scientific research has confirmed a troubling link between the long-term use of Depo-Provera—the injectable birth control shot—and the development of meningioma brain tumors. Women who received Depo-Provera injections and were later diagnosed with meningiomas may now be eligible to file lawsuits against Pfizer, the drug’s manufacturer, for failing to warn about this serious risk. Our lawyers believe this will be an extremely successful mass tort in terms of getting vicitms settlement compensation, as we explain more fully below.
As of August 2025, more than 500 Depo-Provera lawsuits have already been filed and consolidated into a federal multidistrict litigation (MDL-3140) in the Northern District of Florida. These cases allege that Pfizer ignored growing evidence about the tumor risks associated with the drug’s active ingredient, medroxyprogesterone acetate, and failed to update the U.S. label, even after other countries issued warnings.
This page will discuss the Depo Provera brain tumor lawsuits and what you need to know if you have a potential case. Here’s everything you need to know about the Depo-Provera lawsuit, how to join, potential settlement amounts, and what comes next.